"A cliché hunchbacked evil scientist's assistant aspires to become a scientist himself, much to the displeasure of the rest of the evil science community."
John Cusack
as Igor (voice)
Myleene Klass
as Dr. Holzwurm (voice)
Robin Walsh
as Dr. Holzwurm's Igor (voice)
Matt McKenna
as Dr. Herzschlag (voice)
John Cleese
as Dr. Glickenstein (voice)
Steve Buscemi
as Scamper (voice)
Sean Hayes
as Brain (voice)
Eddie Izzard
as Dr. Schadenfreude (voice)
Jay Leno
as King Malbert (voice)
Jennifer Coolidge
as Jaclyn / Heidi (voice)
Molly Shannon
as Eva (voice)
James Lipton
as Himself
Christian Slater
as Dr. Schadenfreude's Igor (voice)
Arsenio Hall
as Carl Cristall (voice)
Jess Harnell
as Announcer / Royal Guard #2 (voice)
Zoë Bright
as Blind Woman / Killiseum Fan #1 (voice)
Sophia Eraklis
as Blind Orphan #1 (voice)
A. Cheron Hall
as Blind Orphan #2 / Blind Orphan #4 (voice)
Alexander Leondis
as Blind Orphan #3 (voice)
Michael Leondis
as Blind Orphan #6 (voice)
Nicole Leondis
as Blind Orphan #7 (voice)
Juliana Leondis
as Blind Orphan #5 (voice)
Robin Tisserand
as Blind Orphan #8 (voice)
Paul Vogt
as Buzz Offmann (voice)
Frank Welker
as Animals' vocal effects (voice) (uncredited)
Tony Leondis
Director
Screenplay
John Hoffman
Dimitri Toscas
Chris McKenna
Steven Clay Hunter
Animation
Jean-Luc De Fanti
Executive Producer
Hervé Schneid
Editor
Darius A. Kamali
Associate Producer
Patrick Doyle
Original Music Composer
Max Howard
Producer
Olivier Besson
Art Direction
Matthew J. Parker
John D. Eraklis
Jamée Deruso
Loïc Rastout
Production Design
Zoltán Maros