"A medical researcher is sent to a plague outbreak, where he has to decide priorities for the use of a vaccine."
Ronald Colman
as Dr. Martin Arrowsmith
Helen Hayes
as Leora Tozer Arrowsmith
Richard Bennett
as Gustav Sondelius
A.E. Anson
as Professor Max Gottlieb
Clarence Brooks
as Dr. Oliver Marchand
Alec B. Francis
as Twyford
Claude King
as Dr. Tubbs
Bert Roach
as Bert Tozer
Myrna Loy
as Joyce Lanyon
Russell Hopton
as Terry Wickett
David Landau
as State Veterinarian
Lumsden Hare
as Sir Robert Fairland
Erville Alderson
as Pioneer (uncredited)
Ward Bond
as Cop (uncredited)
Beulah Bondi
as Mrs. Tozer (uncredited)
Florence Britton
as Miss Twyford (uncredited)
Nora Cecil
as Nurse (uncredited)
Sidney De Gray
as Dr. Hesselink (uncredited)
Cyril Delevanti
as Committee Member (uncredited)
Walter Downing
as City Clerk (uncredited)
Gibson Gowland
Sherry Hall
as Reporter (uncredited)
Theresa Harris
as Native Mother (uncredited)
Raymond Hatton
as Drunk (uncredited)
Charlotte Henry
as Pioneer Girl (uncredited)
George Humbert
as Italian Uncle (uncredited)
DeWitt Jennings
as B.W. Tozer (uncredited)
Mike Lally
Lillian Lawrence
as West Indies Townswoman at Meeting (uncredited)
Carl M. Leviness
as Ship's Passenger (uncredited)
James A. Marcus
as Old Doctor (uncredited)
Eric Mayne
as Dignitary at Luncheon (uncredited)
Kendall McComas
as Little Johnny (uncredited)
Edmund Mortimer
John Qualen
as Henry Novak (uncredited)
Edward Reinach
as Dignitary (uncredited)
Milton Royce
as Intern (uncredited)
Harry Schultz
as Bartender (uncredited)
Pat Somerset
as Ship's Officer (uncredited)
Adele Watson
as Mrs. Novak (uncredited)
Bobby Watson
as Little Neighbor (uncredited)
Eric Wilton
John Ford
Director
Alfred Newman
Music Director
Sinclair Lewis
Novel
Jack Noyes
Sound
Richard Day
Settings
Ray Heindorf
Orchestrator
Sidney Howard
Screenplay
Herbert Sutch
Assistant Director
Samuel Goldwyn
Presenter
Robert McIntyre
Casting
Set Decoration
Producer
Hugh Bennett
Editor
Ray June
Director of Photography
Arthur Hornblow Jr.
Executive Producer
Original Music Composer
